Doctoral researcher in Organoid Intelligence

About the role

The Luxembourg Centre for Systems Biomedicine seeks a motivated doctoral researcher to lead a pioneering project in Organoid Intelligence (OI). You will develop a reservoir‑computing platform where a human brain organoid serves as a living, adaptive computing substrate.

Key responsibilities

• Generate and maintain three‑dimensional human brain organoids from iPSC lines.
• Design and execute high‑density multielectrode array (MEA) stimulation and recording protocols.
• Implement closed‑loop training procedures to study activity‑dependent plasticity and functional connectivity changes.
• Analyze extracellular network activity and map reservoir states to computational tasks using machine‑learning readout layers.
• Collaborate across wet‑lab neurobiology, electrophysiology, and computational analysis teams.

Required profile

• Master’s degree (or equivalent) in neuroscience, bioengineering, biology, biophysics or a closely related discipline.
• Hands‑on experience with MEA technology, including electrophysiological stimulation, recording, and data analysis.
• Strong background in neurobiology, preferably with knowledge of synaptic plasticity, LTP, and neural network dynamics.
• Experience with human stem‑cell culture, iPSC handling, neural differentiation, and brain organoid generation is a strong asset.
• Proficiency in scientific programming (Python or MATLAB) and interest in reservoir computing or machine‑learning concepts.

Required skills

• Multielectrode array (MEA) technology
• Electrophysiological stimulation and recording
• Extracellular network activity analysis
• Human stem‑cell culture and iPSC techniques
• Neural differentiation and brain organoid generation
• Python programming
• MATLAB programming
• Reservoir computing concepts

What we offer

• Integration into a highly interdisciplinary, international research environment.
• Access to state‑of‑the‑art laboratory and computational facilities.
• Opportunities to publish in high‑impact journals and present at international conferences.
• Competitive PhD funding and mentorship from leading experts.